Home  >  Health Encyclopedia  >  Cancer Care

Health Encyclopedia

 

Cancer Care



Certain Factors Help Predict Invasive Breast Cancer

Certain Factors Help Predict Invasive Breast Cancer

A recent study published in the Journal of the National Cancer Institute suggests that 2 factors can help predict the risk of developing future invasive cancer in women with noninvasive breast cancer. This could help women and their doctors make more informed treatment choices. The 2 factors identified in the study were: 

  • Whether the ductal carcinoma in situ (DCIS) was detected as a lump or by mammography

  • Which combinations of biomarkers were present on the DCIS tissue  

Understanding DCIS

DCIS refers to cancer in the breast's milk ducts that has not spread. It is the most common type of noninvasive breast cancer, accounting for about 1 out of every 5 new breast cancer cases in the U.S. DCIS is not deadly, but it raises your risk for future invasive cancer.

Some women with DCIS are treated with lumpectomy alone. In a lumpectomy, the tumor and surrounding tissue are removed. Studies have shown that 5% to 10% of women with DCIS treated by lumpectomy alone develop an invasive form of breast cancer within 5 years. But research trying to identify which of these women are at higher risk has had mixed results.

Method of cancer detection and biomarkers predict risk

To determine risk factors for invasive cancer in women with DCIS, researchers interviewed 1,162 Californian women who had been diagnosed with DCIS and underwent lumpectomy for treatment.

Women whose original DCIS was found when a lump was felt by their doctors were more likely to develop a subsequent invasive cancer as women whose DCIS was found by mammography.

In addition, analysis of DCIS tissue found that several biomarkers predicted risk for developing invasive breast cancer. A biomarker is a substance that is produced by the body and indicates a specific process, condition, or disease. Risk was higher in women with DCIS positive for 3 biomarkers: p16, cyclooxygenase-2, and Ki67.

The study authors think that this information will help doctors to better predict the risk level of developing invasive cancer later for women who are treated with lumpectomy. Those who are at high risk may be better candidates for additional treatment.

Tests that profile the "molecular signature" of breast cancer tissue can be used to predict risk of recurrence and response to treatment.  

Lowering your risk after breast cancer

All forms of breast cancer raise your risk for new cancer. But there are ways to help lower your risk. Talk with your doctor about these tips:

  • Maintain a healthy weight. Being overweight can boost your risk for breast cancer coming back or a new cancer forming.

  • Get active. Research suggests that regular exercise can help lower your risk for a new breast cancer or the original cancer returning.

  • Consider preventive medicines. Ask your doctor if you might be a good candidate for preventive medicines, such as aromatase inhibitors and selective estrogen receptor modulators, which lower the risk for recurrence of certain breast cancers or for new cancers developing.

  • Avoid hormone replacement therapy. Most experts agree that the higher risk for a subsequent cancer outweighs the benefits of hormone replacement therapy in women who have had breast cancer. 

 
Related Items
Wellness Library
  Solving the Breast Cancer Puzzle
  Reducing Your Risk for Breast Cancer
  Hope on the Horizon for Breast Cancer
  Stay Healthy After Breast Cancer
Content Type 167
  BRCA
  CA 15-3
  CA 27-29
  Immunohistochemical Test for Estrogen and Progesterone Receptors
Cancer Source
  Sex and Cancer: Questions for Your Doctor
  Breast Cancer—Understanding Genetic Testing
  The Soy and Breast Cancer Controversy: Cause for Concern?
  The 'Chemobrain' Phenomenon in Breast Cancer
  MRIs for Breast Cancer Screening—Who Needs Them?
  Hormonal Therapy: Managing Side Effects in Women
  If You Are Having Hormonal Therapy
  What Is Breast Cancer?
  What to Know About Your Treatment Choices for Breast Cancer
  Ductal Carcinoma
  Statistics About Breast Cancer
  Can I Get Checked for Breast Cancer Before I Have Symptoms?
  What Can I Do if I Am at Risk for Breast Cancer?
  What Are the Symptoms of Breast Cancer?
  How Does My Doctor Know I Have Breast Cancer?
  Tests That Help Evaluate the Traits of Your Breast Cancer
  Understanding Your Grade and Stage of Breast Cancer
  What to Know About Surgery for Breast Cancer
  Breast Cancer: What Happens After Reconstructive Surgery
  Goal of Chemotherapy for Breast Cancer
  Do What You Can to Ease Side Effects of Treatment and Symptoms for Breast Cancer
  Finding Out You Have Breast Cancer
  What to Know About Combination Therapy for Breast Cancer
  How You Get Radiation for Breast Cancer
  What You Need to Know About Hormone Therapy for Breast Cancer
  Tips for Feeling Your Best During Treatment for Breast Cancer
  Taking Care of Your Incision After Breast Surgery
  How Your Doctor Uses Biopsies to Make Your Diagnosis of Breast Cancer
  Understanding Your Type of Breast Cancer
  What to Know About Inflammatory Breast Cancer (IBC)
  Can I Survive Breast Cancer? What Is My Prognosis?
  Am I at Risk for Breast Cancer?
  Myths About What Causes Breast Cancer
  Questions to Ask About Treatment for Breast Cancer
  What to Expect After Surgery for Breast Cancer
  What Happens During Radiation Therapy for Breast Cancer
  What to Expect After Radiation Treatment for Breast Cancer
  What Happens During Chemotherapy for Breast Cancer
  Making the Decision to Have Hormone Therapy for Breast Cancer
  What Happens During Hormone Therapy for Breast Cancer
  Ovarian Ablation as Hormone Therapy for Breast Cancer
  What to Expect After Taking Hormone Therapy Drugs for Breast Cancer
  What to Know About Targeted Therapy for Breast Cancer
  What Happens During Targeted Therapy for Breast Cancer
  Making the Decision to Have Breast Reconstruction After a Mastectomy for Breast Cancer
  When Breast Cancer Spreads to the Bones
  Exercising After Breast Cancer: Moving Toward Health
  Aromatase Inhibitors for Breast Cancer
Cancer FAQs
  Breast Cancer FAQ
NCI Patient Summary
  Breast Cancer Treatment and Pregnancy (PDQ®)
Quizzes
  Breast Cancer Quiz
MRAs
  Breast Cancer Risk Assessment
Adult Diseases and Conditions
  Breast Cancer Prevention Trial (BCPT)
  Chemotherapy for Breast Cancer Treatment
  About Clinical Trials: Information from the National Cancer Institute
  How Is Breast Cancer Diagnosed?
  General Information About Breast Cancer
  Other Treatments for Breast Cancer
  National Surgical Adjuvant Breast and Bowel Project (NSABP)
  Post-Mastectomy
  Radiation Therapy for Breast Cancer Treatment
  Risk Factors for Breast Cancer
  Signs and Symptoms of Breast Cancer
  Stages of Breast Cancer
  Study of Tamoxifen and Raloxifene (STAR)
  Breast Cancer Statistics
  About Taxol
  Breast Health: Three-Step Plan for Preventive Care
  Treatments for Breast Cancer
  Hereditary Breast Ovarian Cancer Syndrome (BRCA1/BRCA2)
  Genetics of Breast Cancer
  Breast Cancer Overview
Newsletters
  Should You Consider Preventive Drugs for Breast Cancer?
  Should You Be Tested for the Breast Cancer Gene?
Test and Procedures
  Breast Biopsy