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Johnson, Theodore S.

MD, PhD

Specialties: 
Pediatric General and Adolescent Medicine
Pediatric Oncology/Hematology
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Overview Clinical Interests Locations Video

Faculty Title

  • Assistant Professor

Medical Degree

  • Medical College of Georgia

Internship

  • Medical College of Georgia

Residency

  • Medical College of Georgia

Fellowship

  • Cincinnati Children's Hospital Medical Center

Research

  • Neoplastic processes actively create immunosuppressive environments that drive systemic tolerance to cancer cells. Tumors develop exquisitely complex stromal networks that promote growth despite the presence of antigen-presenting cells (APCs) and tumor infiltrating lymphocytes. Although tumor-associated macrophages (TAMs) appear to be fully competent APCs, they process immense volumes of dead and dying tumor cells without inciting adaptive immune responses. Our laboratory uses a variety of solid tumor models to study the role of TAMs in regulating anti-tumor immune responses. We employ an inducible macrophage deletion strategy to study the mechanistic role of TAMs in promoting tumor growth and progression. By inducibly deleting TAMs, we can determine their direct effects on tumor growth and survival, the inflammatory tumor microenvironment and resulting cytokine milieu, and the magnitude of anti-tumor immune responses. We also study the role of TAMs in recruiting inhibitory dendritic cells and regulatory T cells to tumor-draining lymph nodes. The overall objective of these studies is to define the mechanisms by which TAMs promote tumor survival and immune suppression in order to identify therapeutic targets for the development of small-molecule therapies and cellular immunotherapy.

Languages

  • English

Board Info

  • American Board of Pediatrics - Certified
  • American Board of Pediatrics - Pediatric Hematology/Oncology - Certified