Health Encyclopedia

 

Health Encyclopedia Home



Immunotherapy for Bladder Cancer

Immunotherapy for Bladder Cancer

 

immunotherapy
Immunotherapy is sometimes used to make the body's own immune system fight cancer.

Immunotherapy is sometimes called biological therapy. For this therapy, drugs are used to make the body’s own immune system fight cancer. Its goal is to kill cancer cells without having to remove the bladder. It can also help keep the bladder cancer from coming back.

Your doctor may recommend immunotherapy if you have early-stage, superficial bladder cancer. This means the cancer has not spread beyond the lining of your bladder. 

What happens during immunotherapy for bladder cancer?

The most common way to give immunotherapy for bladder cancer is intravesically. That means the drugs are placed directly into your bladder instead of injected into your blood or taken as pills. Early-stage bladder cancer can often be successfully treated with the drug BCG (bacillus Calmette-Guerin). The doctor puts BCG directly into your bladder by inserting it through a catheter in your urethra. Your body’s immune system responds to the presence of BCG and the bladder cancer cells are destroyed.

You go to your doctor’s office to have intravesical immunotherapy. For the 8 to 12 hours before the treatment, you should drink only a small amount of water. In the last 4 hours before the treatment, you should drink no liquids. Your bladder needs to be almost completely emptied for BCG to work.

Your doctor inserts a catheter through your urethra into your bladder. This usually isn’t painful, although you will feel some discomfort when the catheter goes through the urethra. Any urine remaining in the bladder drains out through the catheter. Then your doctor injects the drug into the catheter.

You should do your best not to urinate for at least 2 hours after the drugs are put into your bladder. This allows the drugs to stay in your bladder long enough to kill cancer cells. You will lie flat during this time, and will be asked to change position occasionally to make sure the drugs reach all parts of the bladder lining. After you urinate, the drugs will come out of the bladder in your urine.

Because BCG is made up of live bacteria, it is very important that you follow instructions carefully about handling your urine after receiving the treatment. Wash your hands after urinating. You may be instructed to add bleach to the toilet water for the first few hours after the treatment to kill the bacteria in the urine. 

Your doctor will ask you to drink a lot of water starting about 2 hours after the procedure. This will dilute the drug that remains in your bladder and reduce bladder irritation, fever, and other potential side effects.

You usually have 6 weekly treatments initially. Follow-up treatment is generally scheduled over the next 12 to 24 months. Follow-up treatments may be given once a month or less frequently (for example, every 3 months). 

What to expect after immunotherapy for bladder cancer

Here are some of the side effects that are common with immunotherapy for bladder cancer:

  • Discomfort or burning in the bladder

  • Feeling the need to urinate often

  • Flu-like symptoms, such as chills, fatigue, or fever

These side effects usually go away within a few days after the treatment.

It's normal to have a slight fever after immunotherapy. However, if you have a lingering fever of 101.5°F (38.6°C) or higher or other symptoms that last for more than 2 days, call your doctor. It could be a sign of infection.

 
Related Items
Content Type 134
  Top 10 Cancers Among Men
Drug Reference
  Bacillus Calmette-Guerin Vaccine, BCG
  Cisplatin
  Doxorubicin
  Valrubicin
  Pemetrexed
  Mitomycin
  Thiotepa
  Vinblastine
  Carboplatin
Cancer Source
  I’ve Just Been Told I Have Bladder Cancer
  Statistics of Bladder Cancer
  Am I At Risk for Bladder Cancer?
  What Are the Symptoms of Bladder Cancer?
  How Does My Doctor Know I Have Bladder Cancer?
  Understanding Your Type of Bladder Cancer
  Understanding Your Stage of Bladder Cancer
  What Happens During Radiation Therapy for Bladder Cancer
  What to Know About Chemotherapy for Bladder Cancer
  How Your Doctor Uses Biopsies to Diagnose Bladder Cancer
  Can I Survive Bladder Cancer? What Is My Prognosis?
  Tips for Telling Your Healthcare Team How You Feel During Treatment for Bladder Cancer
  Do What You Can to Ease Treatment Side Effects and Symptoms of Bladder Cancer
  What Happens with Local (Intravesical) Chemotherapy for Bladder Cancer
  What Happens With Systemic Chemotherapy for Bladder Cancer
  What to Expect After Chemotherapy for Bladder Cancer
  What to Expect After Radiation Therapy for Bladder Cancer
  Common Treatment Combinations Based on Your Stage of Bladder Cancer
  What to Know About Cystectomy for Bladder Cancer
  What Happens During Reconstructive Surgery for Bladder Cancer
  What to Expect After Reconstructive Surgery for Bladder Cancer
  Questions to Ask About Treatment for Bladder Cancer
  Making the Decision to Have Surgery for Bladder Cancer
  Making the Decision to Have Chemotherapy for Bladder Cancer
Cancer FAQs
  Frequently Asked Questions: Bladder Cancer
Daily News Feed
  Exercise Linked to Improved Bladder Cancer Survival
Adult Diseases and Conditions
  Bladder Cancer